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Venous ulcers

Open skin sores are ulcers. Any part of the skin might be affected by them. But the legs are where they usually manifest. Leg ulcers, known as venous ulcers, are brought on by issues with blood circulation in your leg veins. Normally, your body begins the healing process to shut the wound as soon as you acquire a cut or scrape. The wound mends with time. But without the right care, ulcers might not recover. These leg vein ulcers can be excruciatingly painful, but we have the perfect treatment for a patient.

Case Study

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Left leg

Chronic wound last 5 years 

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After 10 weeks


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Right leg


After 10 weeks


The American Venous Forum defines venous stasis ulcer as a thick wound or sore on the skin that takes longer than usual time to heal and that is caused by chronic venous diseases. (1) Venous ulcers occur when venous valves fail to function correctly and this most commonly occurs in your legs around the ankle. (2)  Venous ulcers are considered the most important of chronic wounds that affect nearly 1-3% of the U.S. population. (3)

Venous insufficiency leads to pooling of blood in veins, which results in drainage of blood cells and fluids into the skin and other tissues that becomes itchy and thin. The resulting skin condition is called skin dermatitis, the very first sign of venues insufficiency. Tingling, itching, swelling, dull aching, redness and cramping are among other early signs of venous insufficiency. Other signs and symptoms may include:

  • Visible varicose veins on the surface

  • A shallow ulcer covered by yellow tissue and a red base

  • Discolored, hot and warm skin in the surrounding area

  • Leg pain that worsen on standing up

  • In severe cases, pus drainage from the wound with a bad odor.

Sanarever® wound spray offers you the solution

Appropriate and timely venous ulcer management includes topically applied medications, and the use of dressings. Our Clinical study showed that Sanarever® is effective in helping venous ulcers. As a soybean-based concentrate, it is great in the topical management of people with leg ulcers.​

​ The venous ulcer develops when there is a backflow of blood to the ends of your limbs, which weakens the skin and make it harder for the wound to heal.

Wound care in venous ulcers requires creating and maintaining a moist environment on the wound surface. The guidelines from the Wound Healing Society (WHS) suggest the use of wound dressings that provides a moist environment for a venous ulcer to heal. (4)

In a dried out ulcer, with a hard crust and desiccated bed, it will become keratinized and the epidermal cells will not grow, which will easily make the healing of the epidermis stagnate, and it will also make the gauze sticky and get stuck on the wound, making it difficult to change the dressing.

On the other hand, excessive humidity will cause too much fluid to flow out, resulting in wound erosion. This suggests that for proper wound care, it is necessary to maintain a moderate dry-wet balance to keep the epidermal cells in an active state, gradually heal toward the center of the wound, and be easy to remove when changing the dressing .Our “Sanarever® Aqueous Wound Protectant Spray”, is formulated to maintain an ideal balance between dryness and humidity at wound’s surface, allowing it to heal naturally.

Sanarever forms a very thin and breathable protective layer on the skin, which protects it against potential damage from contaminants and also provides protection against maceration of the skin. The fluidity of Sanarever's biomaterial allows it to penetrate deeply into the wound bed, which stimulates acute inflammation and the gradual disposition of new extracellular matrix at an early stage.

If untreated, the ulcers become infected with microbes. Sanarever® as topical probiotics in a soybean based liquid dressing, helps prevent antibiotic resistance and prevents the further spread of infection.

This way, Sanarever plays a role in promoting skin renewal and wound healing, both of which require an optimal environment for removing damaged or aged tissues.

Sanarever® has been proven to promote wound healing and prevent venous ulcers, by helping in inflammation, increasing re-epithelialization, and re-vascularization, and preventing infection & biofilm formation.

Not all inflammations are bad. During the first phase of wound healing, Sanarev induces an influx of inflammatory cells such as macrophages and polymorphonuclear leukocytes to minimize bacterial counts and help wound healing. This also involves the prevention of further infection, and prevention of biofilms formation. This has also shown the ability to improve vascularization and epithelialization. Sanarever® also increases collagen levels and capillary vessels when wounds are examined microscopically.

Our clinical trials have shown that soy protein has bioactive peptides similar to ECM proteins present in human tissues. Soy protein offers a safe alternative to animal protein and endogenous estrogen in promoting superficial wound healing. Cryptic peptides in it accelerate the synthesis of the skin’s ECM, and activate the skin’s re epithelization to promote wound healing. This ECM mimicking action of these peptides stimulates tissue regeneration by promoting cell adhesion, generation, and migration.

​In Sanarever, the formulation of probiotics in soybean-based concentrate is prepared in a liquid state. This approach gives it the additional benefit that it can be sprayed in an even distribution over the entire surface of the ulcer, even in wounds with irregular surfaces where some dressings might find it difficult to conform to the surface of the wound. It is extremely easy to apply, even for patients at home, with little concern that spraying the solution on surrounding normal skin would lead to maceration of the skin.

Beyond providing a moist environment for the ulcer to heal, the Wound healing society provides the following guidelines when deciding on treatment options.

For venous ulcers, compression therapy is the first treatment option with a bilayer artificial skin. This is even better than simple dressing and compression.

Antibiotics are only recommended to treat infected ulcers, but they do not help the actual ulcer to heal. Venous ulcers may cause rash development in some people which become itchy and irritated. Sanarever helps with the itchy wounds.

Take away:

Sanarever could help you heal wounds in venous ulcers and their related infections. But unless the underlying cause of the disease is not addressed, it will recur after the treatment and no wound spray will be effective. Obesity, immobility, and varicose veins are among the most common underlying causes. (5)


  1. O'Donnell TF, Passman MA, Marston WA, Ennis WJ, Dalsing M, Kistner RL, et al. (August 2014). "Management of venous leg ulcers: clinical practice guidelines of the Society for Vascular Surgery ® and the American Venous Forum". Journal of Vascular Surgery. 60 (2 Suppl): 3S–59S. doi:10.1016/j.jvs.2014.04.049PMID 24974070.

  2. James WD, Berger TG, Elston DM (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 978-0-7216-2921-6OCLC 968428064.

  3. Lal BK (March 2015). "Venous ulcers of the lower extremity: Definition, epidemiology, and economic and social burdens". Seminars in Vascular Surgery. 28 (1): 3–5. doi:10.1053/j.semvascsurg.2015.05.002PMID 26358303.



How to use

First, Disinfect the wound with Povidone iodine and then rinse with sterile saline or water, and then apply/spray Sanarever® Aqueous Wound Protectant Spray from 2 to 4 inches above onto every 0.8 x 0.8 inch of the target area. Spray 1 to 3 times a day, this product is not waterproof, may be covered with a sterile bandage. if bandaged, let dry first.


The wound must be disinfected with sterile saline, before applying this solution, and avoid this getting into your eyes. 

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