Diabetic ulcers

Wound healing is the body’s built in mechanism to repair itself and it works reliably most of the times. It consists of repairing the lost extra cellular matrix that comprises the largest part of the outermost skin layer. (1) Unfortunately, a few physical insults impair the body’s natural healing system. Diabetes mellitus is one of them. Studies on diabetic wounds have shown a prolonged inflammatory phase, which leads to a delayed formation of mature granulation tissues and a decreased wound tensile strength. (2)

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Diabetic foot ulcers are further divided into two types. Neuropathic ulcers are those formed in neuropathic feet and neuroischemic ulcers are those formed in feet with ischemia associated with neuropathy.

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 The most common causes of diabetic foot ulcers are impaired blood circulation, hyperglycemia, and nerve damage. Studies show that almost 15% of patients with diabetes develop a diabetic foot ulcer and 84% of cases lead to diabetes related lower leg imputation. (3, 4)

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 Diabetic ulcer healing depends on various factors including its size and location, pressure on the wound while the patient walks or stands up, wound care, blood glucose level, and most importantly, what is being applied to the ulcer.

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Diabetic ulcer management

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The first and foremost goal in diabetic foot ulcer care is healing the wound immediately to prevent it getting infected. (5)

Following are the key steps needed for diabetic foot ulcer management:

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• Preventing the wound from getting infected

• Taking the pressure off the area, called “off-loading”

• Removing dead skin and tissue, called “debridement”

• Providing a moist environment to the wound

• Applying medication or dressings to the ulcer

• Epithelization and re vascularization of the ischemic limb

• Managing blood glucose and other health problems

 

Appropriate wound management includes the use of dressings and topically-applied medications e.g. normal saline or highly effective advanced wound care products like growth factors and skin substitutes.

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Such wound care can be achieved by choosing a suitable topical regime that offers both standard and advanced topical therapies.

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Our solution- Sanarever® wound protectant spray

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Sanarever® is bringing you the ultimate solution to diabetic ulcers. Our Clinical study showed that Sanarever® is effective in helping small foot ulcers that do not involve bone or tendon exposure. As a soybean-based concentrate, it is great in the topical management of people with diabetic foot ulcers.​

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Sanarever® is topical probiotic in a soybean based  liquid dressing in promoting skin renewal and wound healing, both of which require an optimal environment for removing damaged or aged tissues. This process involves inflammation, which is helpful in the first phase of wound healing. (6)

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Not all inflammations are bad, as, during the first phase of wound healing, it induces an influx of inflammatory cells such as macrophages and polymorphonuclear leukocytes to minimize bacterial counts and help wound healing. This also involves the prevention of further infection, and prevention of biofilms formation. This has also shown the ability to improve vascularization and epithelialization.  Sanarever® also increases collagen levels and capillary vessels when wounds are examined microscopically.

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Our clinical trials have shown that soy protein has bioactive peptides similar to ECM proteins present in human tissues. Soy protein offers a safe alternative to animal protein and endogenous estrogen in promoting superficial wound healing. Cryptic peptides in it accelerate the synthesis of the skin’s ECM, and activate the skin’s re epithelization to promote wound healing. This ECM mimicking action of these peptides stimulates tissue regeneration by promoting cell adhesion, generation, and migration.

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Moreover, for proper wound care, it is necessary to maintain a moderate dry-wet balance to keep the epidermal cells in an active state, gradually heal toward the center of the wound, and be easy to remove when changing the dressing. Our “Sanarever® Aqueous Wound Protectant Spray”, is formulated to maintain an ideal balance between dryness and humidity at the wound’s surface, allowing it to heal naturally.

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Our solution involves probiotic-based water-based wound dressing. This helps in keeping the wound moist, avoiding drying, and helps in healing. This is mild and non-irritating, absorbs faster, and keeps the wound moist. You can apply our wound dressing to decubitus wounds, chronic wounds, burn wounds, difficult-to-heal wounds, and last but not least diabetic foot wounds.

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For diabetic ulcers, evaluation of their characteristics followed by the use of suitable adjuvants is recommended. Not all ulcers are infected; however, if your get diagnosed with an infection, proper wound care, topical medication, antibiotic program and possibly hospitalization must be considered.

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Therefore, we recommend that while the wound is small, control it with Sanarever to avoid the wound from hurting the nerves. For diabetic foot ulcers, if the wound is deeper, we will suggest using Sanarever® Diabetic Wound Care Gel, which can cover the wound well.

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